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Biofarmasetika dan Farmakokinetika Terapan: A Comprehensive Guide for Pharmacy Students
Biofarmasetika dan Farmakokinetika Terapan (Applied Biopharmaceutics and Pharmacokinetics) is a book written by Fasich and Budi Suprapti, two professors from Airlangga University in Indonesia. The book covers the basic principles and applications of biopharmaceutics and pharmacokinetics in pharmacy practice, such as drug absorption, distribution, metabolism, excretion, bioavailability, bioequivalence, pharmacokinetic models, dosage regimen design, pharmacokinetic interactions, and pharmacogenetics.
The book is intended for pharmacy students who want to learn the fundamentals of biopharmaceutics and pharmacokinetics as well as their clinical implications. The book is written in Indonesian language and uses examples and case studies relevant to the Indonesian context. The book also provides exercises and review questions at the end of each chapter to help students assess their understanding of the topics.
The fifth edition of the book was published in 2012 by Airlangga University Press. The book is available in print and digital formats. The ebook version can be downloaded from the UNAIR Repository website[^2^]. The ebook is in PDF format and has 33 MB size. The ebook can be accessed for free by anyone who has an internet connection.
Biofarmasetika dan Farmakokinetika Terapan is a useful resource for pharmacy students who want to master the concepts and skills of biopharmaceutics and pharmacokinetics. The book is also suitable for pharmacy practitioners who want to update their knowledge and practice evidence-based pharmacotherapy.
In this article, we will discuss some of the key topics covered in the book Biofarmasetika dan Farmakokinetika Terapan. We will explain the concepts and applications of drug absorption, bioavailability, pharmacokinetic models, and dosage regimen design.
Drug absorption is the process by which a drug enters the systemic circulation from its site of administration. Drug absorption depends on several factors, such as the physicochemical properties of the drug, the formulation and route of administration, the physiological conditions of the absorption site, and the presence of other substances that may affect drug absorption.
The book describes the different routes of drug administration, such as oral, parenteral, topical, inhalational, and rectal. The book also explains the mechanisms and factors that influence drug absorption through these routes, such as dissolution, diffusion, permeation, first-pass effect, pH-partition hypothesis, and bioadhesive systems.
The book also discusses the methods and techniques to measure drug absorption, such as in vitro dissolution testing, in vivo bioavailability studies, and pharmacokinetic analysis. The book provides examples and calculations to illustrate how to apply these methods and techniques in practice.
Bioavailability is the extent and rate at which a drug reaches the systemic circulation from its site of administration. Bioavailability reflects the efficiency of drug absorption and the effect of first-pass metabolism. Bioavailability is an important parameter to evaluate the quality and equivalence of drug products.
The book defines the concepts and terms related to bioavailability, such as absolute bioavailability, relative bioavailability, bioequivalence, therapeutic equivalence, generic drugs, and reference drugs. The book also explains the factors that affect bioavailability, such as drug formulation, physicochemical properties of the drug, physiological conditions of the patient, and pharmacokinetic interactions.
The book also describes the methods and designs to conduct bioavailability and bioequivalence studies, such as single-dose studies, multiple-dose studies, crossover studies, parallel studies, and replicate studies. The book also discusses the statistical analysis and interpretation of bioavailability and bioequivalence data. The book provides examples and case studies to demonstrate how to perform bioavailability and bioequivalence studies in practice. 061ffe29dd